Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | CLK3 | P49761 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3251903 | 0.90 | LMNA (0.47) | GPR119SMN1; SMN2 | |
| SCHEMBL3241101 | 0.88 | GPR119 (0.59) | GPR119 | |
| SCHEMBL3246751 | 0.87 | GPR119 (0.47) | GPR119SMN1; SMN2CLK2CLK3DYRK1A | |
| SCHEMBL3119362 | 0.82 | GPR119 (0.49) | GPR119SMN1; SMN2 | |
| SCHEMBL3237101 | 0.80 | RAB9A (0.37) | GPR119SMN1; SMN2SMYD3RAB9ARXFP1 | |
| SCHEMBL3243152 | 0.78 | GPR119 (0.49) | GPR119SMN1; SMN2 | |
| SCHEMBL3238582 | 0.76 | GPR119 (0.48) | GPR119SMN1; SMN2 | |
| SCHEMBL3244500 | 0.74 | GPR119 (0.46) | GPR119SMN1; SMN2 | |
| SCHEMBL3118783 | 0.71 | GPR119 (0.51) | GPR119 | |
| SCHEMBL3130130 | 0.71 | GPR119 (0.53) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001166-A1 | THIAZOLE DERIVATIVES AS GPR 119 MODULATORS | PROSIDION LIMITED (GB) | 2010-01-07 | — | — | WO | claimed |