Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6216338 | 0.83 | COMT (0.60) | KMT2AMEN1KDM4EALDH1A1GAA | |
| SCHEMBL1333403 | 0.82 | COMT (0.63) | KMT2AMEN1GLATSHRKDM4E | |
| SCHEMBL1506959 | 0.82 | HTR1A (0.53) | KMT2AMEN1GLATSHRKDM4E | |
| SCHEMBL14919706 | 0.76 | FTO (0.63) | KMT2AMEN1GLATSHRKDM4E | |
| SCHEMBL1332026 | 0.76 | KMT2A (0.62) | KMT2AMEN1GLATSHRKDM4E | |
| SCHEMBL9186410 | 0.76 | KMT2A (0.55) | KMT2AMEN1GLATSHRKDM4E | |
| SCHEMBL4977841 | 0.75 | KMT2A (0.49) | KMT2AMEN1GLATSHRKDM4E | |
| SCHEMBL3156151 | 0.75 | KMT2A (0.59) | KMT2AMEN1GLATSHRKDM4E | |
| SCHEMBL11438355 | 0.74 | KDM4E (0.54) | KMT2AMEN1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4022814 | 0.74 | PDE4A (0.64) | KMT2AMEN1GLATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227803-B1 | COMPOUNDS FOR INHIBITING IAPP-ASSOCIATED AMYLOID DEPOSITS | BELLUS HEALTH INTERNATIONAL LTD (CH) | 2010-05-05 | — | — | EP | disclosed |