Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244695 | 0.94 | CYP1A2 (0.48) | ALDH1A1MAPTLMNAHTTTSHR | |
| SCHEMBL3253240 | 0.91 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNAHTTTSHR | |
| SCHEMBL3246435 | 0.90 | ALDH1A1 (0.42) | ALDH1A1MAPTLMNAHTTTSHR | |
| SCHEMBL3251363 | 0.89 | SMN1; SMN2 (0.43) | ALDH1A1MAPTLMNAHTTMEN1 | |
| SCHEMBL3251156 | 0.89 | FLT1 (0.42) | ALDH1A1MAPTLMNAHTTMEN1 | |
| SCHEMBL4869106 | 0.89 | TSHR (0.47) | ALDH1A1MAPTLMNATSHRERBB2 | |
| SCHEMBL3250956 | 0.89 | CTSS (0.47) | ALDH1A1MAPTLMNAHTTMEN1 | |
| SCHEMBL3249174 | 0.88 | L3MBTL1 (0.44) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL3252376 | 0.88 | MEP1B (0.53) | ALDH1A1MAPTLMNAHTTTSHR | |
| SCHEMBL3253080 | 0.86 | FDFT1 (0.40) | ALDH1A1MAPTLMNAMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776347-B1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI AVENTIS (FR) | 2010-05-26 | — | — | EP | disclosed |
| US-7396958-B2 | Sulphonamide derivatives, their preparation and their therapeutic application | SANOFI AVENTIS (FR) | 2008-07-08 | — | — | US | disclosed |