Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.60 |
| ▸ | BCR | P11274 | 2/20 | 0.60 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245571 | 0.88 | ABL1 (0.59) | ABL1BCRCTSCEGFRITK | |
| SCHEMBL3244032 | 0.86 | KDR (0.48) | CTSCBRAF | |
| SCHEMBL3243019 | 0.85 | LCK (0.55) | ABL1BCRSCN9AJAK1TYK2 | |
| SCHEMBL3247802 | 0.84 | BRAF (0.58) | ABL1CTSCBRAFEGFRITK | |
| SCHEMBL3235430 | 0.81 | CTSC (0.46) | ABL1CTSCBRAFEGFRITK | |
| SCHEMBL3247795 | 0.81 | BRAF (0.46) | CTSCBRAFEGFR | |
| SCHEMBL3242880 | 0.81 | BRAF (0.54) | ABL1BCRCTSCBRAFEGFR | |
| SCHEMBL3249551 | 0.80 | CTSC (0.45) | ABL1BCRCTSCBRAFEGFR | |
| SCHEMBL3245525 | 0.80 | AURKA (0.47) | ABL1BCRCTSCEGFRITK | |
| SCHEMBL3245277 | 0.80 | ABL1 (0.55) | ABL1BCRCTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |