Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.59 |
| ▸ | BCR | P11274 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | CTSC | P53634 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247799 | 0.88 | ABL1 (0.60) | ABL1BCRCTSCEGFRITK | |
| SCHEMBL3247802 | 0.83 | BRAF (0.58) | ABL1KDM4EMAPTMAPK1DYRK1A | |
| SCHEMBL3245525 | 0.83 | AURKA (0.47) | ABL1BCRKDM4EMAPTMAPK1 | |
| SCHEMBL3244032 | 0.82 | KDR (0.48) | CTSC | |
| SCHEMBL3247964 | 0.81 | CTSC (0.49) | ABL1BCRSYKCTSCEGFR | |
| SCHEMBL3235430 | 0.81 | CTSC (0.46) | ABL1SYKCTSCEGFRITK | |
| SCHEMBL3247795 | 0.81 | BRAF (0.46) | CTSCEGFR | |
| SCHEMBL3234950 | 0.80 | CTSC (0.52) | ABL1MAPTDYRK1ASYKCTSC | |
| SCHEMBL3249551 | 0.80 | CTSC (0.45) | ABL1BCRSYKCTSCEGFR | |
| SCHEMBL3242880 | 0.80 | BRAF (0.54) | ABL1BCRMAPTSYKCTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |