Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9571716 | 0.70 | HTR2A (0.39) | — | |
| SCHEMBL5059600 | 0.69 | HTR2A (0.36) | — | |
| SCHEMBL6582543 | 0.69 | OPRM1 (0.40) | — | |
| SCHEMBL5187018 | 0.64 | GRIN1 (0.40) | — | |
| SCHEMBL2180899 | 0.61 | — | — | |
| SCHEMBL4722162 | 0.60 | ALOX5 (0.34) | ADRA2AADRA2BADRA2C | |
| SCHEMBL4529279 | 0.60 | USP2 (0.31) | — | |
| SCHEMBL10261142 | 0.59 | SIGMAR1 (0.58) | — | |
| SCHEMBL6971939 | 0.59 | SIGMAR1 (0.41) | — | |
| SCHEMBL4720537 | 0.58 | HTR1A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899350-B1 | PYRAZOLO [3 , 4-D]AZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2010-05-12 | — | — | EP | disclosed |
| EP-1899350-A1 | PYRAZOLO Ý3 , 4-D¨AZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007025596-A1 | PYRAZOLO [3 , 4-D] AZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |