Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.66 |
| ▸ | MGLL | Q99685 | 1/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244603 | 0.88 | ROCK2 (0.58) | ROCK2MGLLROCK1NPC1RAB9A | |
| SCHEMBL3243298 | 0.86 | ROCK2 (0.70) | ROCK2ROCK1 | |
| SCHEMBL20262080 | 0.85 | ROCK2 (0.52) | ROCK2MGLLROCK1EPHX1NPC1 | |
| SCHEMBL3246002 | 0.85 | ROCK2 (0.72) | ROCK2ROCK1 | |
| SCHEMBL10133046 | 0.85 | MGLL (0.65) | MGLLEPHX1NPC1RAB9AADAMTS4 | |
| SCHEMBL3249896 | 0.83 | ROCK2 (0.53) | ROCK2ROCK1 | |
| SCHEMBL17552096 | 0.82 | NPC1 (0.69) | MGLLEPHX1NPC1RAB9AADAMTS4 | |
| SCHEMBL27744398 | 0.81 | EPHX1 (0.70) | ROCK2MGLLROCK1EPHX1NPC1 | |
| SCHEMBL3263754 | 0.81 | ROCK2 (0.70) | ROCK2ROCK1 | |
| SCHEMBL9124263 | 0.81 | MGLL (0.61) | MGLLEPHX1NPC1RAB9AADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |