Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253944 | 0.87 | SMN1; SMN2 (0.38) | MEN1KMT2AMAPTSMN1; SMN2HPGD | |
| SCHEMBL3253941 | 0.87 | SMN1; SMN2 (0.38) | MEN1KMT2AMAPTSMN1; SMN2HPGD | |
| SCHEMBL3254619 | 0.85 | ALOX15 (0.44) | MEN1KMT2AMAPTHPGDKDM4E | |
| SCHEMBL3255449 | 0.84 | TTR (0.43) | MEN1KMT2AMAPTSMN1; SMN2HPGD | |
| SCHEMBL3248489 | 0.83 | MEN1 (0.41) | MEN1KMT2AMAPTSMN1; SMN2TYR | |
| SCHEMBL3248486 | 0.83 | MEN1 (0.41) | MEN1KMT2AMAPTSMN1; SMN2TYR | |
| SCHEMBL4155737 | 0.81 | MEN1 (0.43) | MEN1KMT2AKDM4EALDH1A1HDAC3 | |
| SCHEMBL3255154 | 0.81 | IP6K1 (0.39) | MEN1KMT2AMAPTSMN1; SMN2HPGD | |
| SCHEMBL3251387 | 0.77 | POLB (0.40) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| Propionic Acid SCHEMBL4155740 | 0.76 | MEN1 (0.40) | MEN1KMT2AMAPTSMN1; SMN2TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |