Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6478895 | 0.72 | PDGFRB (0.57) | AURKADAPK3JAK2PRKD3MAP4K4 | |
| SCHEMBL14214631 | 0.67 | KDR (0.84) | AURKADAPK3JAK2PRKD3MAP4K4 | |
| SCHEMBL16611976 | 0.62 | TUBB4A (0.52) | AURKADAPK3JAK2PRKD3MAP4K4 | |
| SCHEMBL10673852 | 0.62 | ALDH1A1 (0.50) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL17067809 | 0.61 | ALDH1A1 (0.53) | PDGFRBKDRKDM4EALDH1A1NPSR1 | |
| SCHEMBL156256 | 0.61 | NOTUM (0.82) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL10621375 | 0.61 | EED (0.52) | KDM4EALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL424604 | 0.61 | CYP3A4 (0.65) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL5759792 | 0.61 | KDR (0.49) | AURKADAPK3JAK2PRKD3MAP4K4 | |
| SCHEMBL13911376 | 0.60 | ALDH1A1 (0.50) | JAK2JAK3PTK2ROCK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |