Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 6/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 4/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | PRKX | P51817 | 1/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.36 |
| ▸ | TSSK3 | Q96PN8 | 1/20 | 0.36 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.36 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.36 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.36 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243094 | 0.86 | GABRA1 (0.41) | PDE2ACYP1A2HSD17B10GABRA1GABRG2 | |
| SCHEMBL3249100 | 0.84 | HNF4A (0.44) | CYP1A2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL3248945 | 0.83 | GABRA1 (0.42) | CYP1A2HSD17B10GABRA1GABRG2GABRB3 | |
| SCHEMBL4162287 | 0.83 | HPGD (0.38) | PIKFYVETTBK1PDE2AGABRA1GABRG2 | |
| SCHEMBL3252127 | 0.82 | CYP1A2 (0.42) | CYP1A2HSD17B10GABRA1GABRG2GABRB3 | |
| SCHEMBL3245806 | 0.81 | TBK1 (0.43) | PIKFYVECYP1A2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL3254573 | 0.77 | HAO1 (0.41) | HAO1 | |
| SCHEMBL3242861 | 0.76 | HSD17B10 (0.38) | CYP1A2HSD17B10GABRA1GABRA3KDM4E | |
| SCHEMBL3247723 | 0.76 | FASN (0.42) | CYP1A2HSD17B10 | |
| SCHEMBL3245050 | 0.76 | PARP1 (0.44) | CYP1A2HSD17B10L3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | claimed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |