Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PIKFYVE | Q9Y2I7 | 6/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.37 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.33 |
| ▸ | TSSK3 | Q96PN8 | 1/20 | 0.33 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.33 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4160294 | 0.86 | FFAR1 (0.48) | HPGDCYP2C19GPR17FFAR1FFAR4 | |
| SCHEMBL4160259 | 0.85 | GABRA1 (0.41) | HPGDCYP2C19GPR17GABRA1GABRG2 | |
| SCHEMBL4155562 | 0.83 | MET (0.39) | HPGDCYP2C19PIKFYVEGPR17FFAR1 | |
| SCHEMBL4165404 | 0.83 | HPGD (0.42) | HPGDCYP2C19GPR17GABRA1GABRG2 | |
| SCHEMBL3248798 | 0.83 | PIKFYVE (0.39) | HPGDPDE2APIKFYVETTBK1MAP3K14 | |
| SCHEMBL4162419 | 0.80 | HPGD (0.39) | HPGDCYP2C19GPR17GABRA1FFAR1 | |
| SCHEMBL4159518 | 0.79 | FFAR1 (0.50) | HPGDCYP2C19GPR17FFAR1FFAR4 | |
| SCHEMBL4169903 | 0.78 | HTR1A (0.47) | HPGDCYP2C19GPR17APEX1 | |
| SCHEMBL4155216 | 0.78 | GSK3B (0.40) | HPGDCYP2C19GPR17 | |
| SCHEMBL4169910 | 0.78 | HPGD (0.44) | HPGDCYP2C19GPR17APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | claimed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | claimed |
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | disclosed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | MAP3K1, MAP3K2, MAP3K7 | HPGD 882/4885CYP2C19 4277/4885PDE2A 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.