Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.42 |
| ▸ | PARG | Q86W56 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | TP53 | P04637 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249535 | 0.92 | TDP1 (0.51) | TDP1PARGBRAFPDE4APDE4B | |
| SCHEMBL3255447 | 0.91 | TDP1 (0.52) | TDP1PARGPDE4APDE4BPDE4C | |
| SCHEMBL3250757 | 0.90 | PARG (0.46) | TDP1PARGKDRBRAFPDE4A | |
| SCHEMBL3254149 | 0.87 | TDP1 (0.43) | TDP1PARGKDRBRAFPDE4A | |
| SCHEMBL3242768 | 0.84 | PARG (0.45) | TDP1PARGKDRBRAFPOLB | |
| SCHEMBL3253874 | 0.83 | TDP1 (0.52) | TDP1PARGPOLBMAPTTP53 | |
| SCHEMBL3250686 | 0.83 | TDP1 (0.52) | TDP1PARGPOLBMAPTTP53 | |
| SCHEMBL3254875 | 0.82 | PARG (0.43) | TDP1PARGKDRBRAFPOLB | |
| SCHEMBL4159503 | 0.82 | PARG (0.43) | TDP1PARGKDRBRAFPOLB | |
| SCHEMBL3250591 | 0.81 | PARG (0.48) | TDP1PARGBRAFPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |