Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249535 | 0.93 | TDP1 (0.51) | PARGTDP1BRAFPDE4APDE4B | |
| SCHEMBL3255447 | 0.92 | TDP1 (0.52) | PARGTDP1PDE4APDE4BPDE4C | |
| SCHEMBL3254875 | 0.92 | PARG (0.43) | PARGTDP1BRAFKDRHSD17B10 | |
| SCHEMBL3245494 | 0.90 | PARG (0.42) | PARGTDP1BRAFKDRSMN1; SMN2 | |
| SCHEMBL3249352 | 0.90 | TDP1 (0.42) | PARGTDP1BRAFKDRPDE4A | |
| SCHEMBL3253869 | 0.89 | PARG (0.41) | PARGTDP1BRAFKDRSMN1; SMN2 | |
| SCHEMBL3252200 | 0.88 | PARG (0.41) | PARGTDP1BRAFKDRSMN1; SMN2 | |
| SCHEMBL3250591 | 0.86 | PARG (0.48) | PARGTDP1BRAFHSD17B10SMN1; SMN2 | |
| SCHEMBL3255208 | 0.86 | PARG (0.48) | PARGTDP1BRAFKDRPDE4A | |
| SCHEMBL3251597 | 0.84 | PARG (0.47) | PARGTDP1BRAFHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |