Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250686 | 0.96 | TDP1 (0.52) | PARGTDP1POLBTSHRCYP3A4 | |
| SCHEMBL3253874 | 0.96 | TDP1 (0.52) | PARGTDP1POLBTSHRCYP3A4 | |
| SCHEMBL3254875 | 0.95 | PARG (0.43) | PARGTDP1POLBBRAFTSHR | |
| SCHEMBL3251597 | 0.93 | PARG (0.47) | PARGTDP1POLBBRAFTSHR | |
| SCHEMBL3242986 | 0.92 | PARG (0.40) | PARGTDP1POLBBRAFTSHR | |
| SCHEMBL3245494 | 0.88 | PARG (0.42) | PARGTDP1POLBBRAFTSHR | |
| SCHEMBL3248591 | 0.88 | TAS2R14 (0.43) | TDP1POLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL3249535 | 0.88 | TDP1 (0.51) | PARGTDP1POLBBRAFALDH1A1 | |
| SCHEMBL3253869 | 0.87 | PARG (0.41) | PARGTDP1POLBBRAFTSHR | |
| SCHEMBL3255447 | 0.87 | TDP1 (0.52) | PARGTDP1POLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |