Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | PARG | Q86W56 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249535 | 0.99 | TDP1 (0.51) | TDP1PARGSMN1; SMN2GAAPDE4A | |
| SCHEMBL3250757 | 0.92 | PARG (0.46) | TDP1PARGSMN1; SMN2GAAPDE4A | |
| SCHEMBL3253874 | 0.91 | TDP1 (0.52) | TDP1PARGSMN1; SMN2GAATP53 | |
| SCHEMBL3250686 | 0.91 | TDP1 (0.52) | TDP1PARGSMN1; SMN2GAATP53 | |
| SCHEMBL3249352 | 0.91 | TDP1 (0.42) | TDP1PARGSMN1; SMN2GAAPDE4A | |
| SCHEMBL3250591 | 0.87 | PARG (0.48) | TDP1PARGSMN1; SMN2GAAKMT2A | |
| SCHEMBL3254035 | 0.86 | TDP1 (0.43) | TDP1PARGSMN1; SMN2GAAPDE4A | |
| SCHEMBL3252622 | 0.85 | TDP1 (0.54) | TDP1PARGSMN1; SMN2GAAPDE4A | |
| SCHEMBL3251597 | 0.85 | PARG (0.47) | TDP1PARGSMN1; SMN2GAATP53 | |
| SCHEMBL3251014 | 0.84 | TDP1 (0.53) | TDP1PARGSMN1; SMN2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |