Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 7/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPY2R | P49146 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245844 | 0.82 | CYP1A2 (0.54) | ATMCYP1A2CYP1A1CYP1B1CYP2D6 | |
| SCHEMBL8646793 | 0.79 | ATM (0.57) | ATMCYP1A2CYP1A1CYP1B1CYP2D6 | |
| SCHEMBL8646796 | 0.79 | ATM (0.57) | ATMCYP1A2CYP1A1CYP1B1CYP2D6 | |
| SCHEMBL10689718 | 0.77 | ALDH1A1 (0.61) | ATMCYP1A2CYP1A1CYP1B1CYP2D6 | |
| SCHEMBL10771685 | 0.75 | ATM (0.56) | ATMCYP1A2CYP1A1CYP1B1CYP2D6 | |
| SCHEMBL3251236 | 0.74 | CYP1A1 (0.71) | CYP1A2CYP1A1CYP1B1CYP2D6ALDH1A1 | |
| SCHEMBL15395615 | 0.72 | PLOD2 (0.65) | ATMCYP1A2CYP1A1CYP1B1CYP2D6 | |
| SCHEMBL16105323 | 0.71 | ALDH1A1 (0.54) | ATMCYP1A2CYP1A1CYP1B1CYP2D6 | |
| SCHEMBL3164380 | 0.71 | ALDH1A1 (0.54) | ATMCYP1A2CYP1A1CYP1B1CYP2D6 | |
| SCHEMBL28677805 | 0.71 | ALDH1A1 (0.78) | ATMCYP1A2CYP2D6ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1167366-B1 | AMINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2010-05-05 | — | — | EP | disclosed |
| US-6562849-B1 | Amine compound or pharmacologically acceptable salt thereof. These compounds are useful in the treatment and/or prophylaxis of diseases such as diabetes, hyperlipemia, arteriosclerosis, cancer, etc. | SANKYO COMPANY, LIMITED (JP) | 2003-05-13 | — | — | US | disclosed |
| US-20030078426-A1 | Amine derivative compounds | SANKYO COMPANY, LIMITED (JP) | 2003-04-24 | — | — | US | disclosed |
| EP-1167366-A1 | AMINE DERIVATIVES | Sankyo Company, Limited (JP) | 2002-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078426-A1 | Amine derivative compounds | H1-10, APOB, PRMT1 | ATM 225/4885CYP1A2 1561/4885CYP1A1 699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.