Nitrogen

Nitrogen

SCHEMBL3249439

N#N.O.O=S(=O)(O)c1ccccc1

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12

The experimentally established mechanism targets of Nitrogen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.84
SMN1; SMN2 Q16637 1/20 0.84
POLB P06746 1/20 0.56
CYP2D6 P10635 1/20 0.56
LMNA P02545 1/20 0.50
HTR6 P50406 1/20 0.50
ALDH1A1 P00352 4/20 0.48
NT5E P21589 1/20 0.48
TDP1 Q9NUW8 3/20 0.46
HSD17B10 Q99714 2/20 0.46
NAPRT Q6XQN6 1/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
MMP1 P03956 1/20 0.46
MMP2 P08253 1/20 0.46
MMP9 P14780 1/20 0.46
MMP8 P22894 1/20 0.46
MMP13 P45452 1/20 0.46
CA12 O43570 1/20 0.46
CA3 P07451 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nitrogen SCHEMBL6034702 0.97 TSHR (0.89) TSHRSMN1; SMN2POLBCYP2D6LMNA
Nitrogen SCHEMBL29220043 0.95 TSHR (0.84) TSHRSMN1; SMN2POLBCYP2D6LMNA
Water SCHEMBL9212693 0.95 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6LMNA
Water SCHEMBL28988244 0.95 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6LMNA
Water SCHEMBL912228 0.95 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6LMNA
Water SCHEMBL3932080 0.95 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6LMNA
Water SCHEMBL338461 0.95 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6LMNA
Water SCHEMBL9064629 0.95 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6LMNA
Water SCHEMBL8617710 0.92 TSHR (0.89) TSHRSMN1; SMN2POLBCYP2D6LMNA
Water SCHEMBL2863471 0.92 TSHR (0.89) TSHRSMN1; SMN2POLBCYP2D6LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180099905-A1 WATERFASTNESS, SMEARFASTNESS, WEAR RESISTANCE, TOUGHNESS AND OVERALL MATERIAL DURABILITY ENHANCING NANO ADDITIVE HK INVESTMENT PRODUCTION TRADING (VN) 2018-04-12 US disclosed
EP-1225205-B1 Carbon black reacted with diazonium salts and products CABOT CORP (US) 2010-10-06 EP disclosed
EP-1942156-B1 Carbon black reacted with diazonium salts and products CABOT CORP (US) 2010-04-14 EP disclosed
EP-1942156-A1 Carbon black reacted with diazonium salts and products Cabot Corporation (US) 2008-07-09 EP disclosed
US-7294185-B2 In absence of exterior applies electrical current; wear resistance CABOT CORPORATION (US) 2007-11-13 US disclosed
EP-0799281-B2 CARBON BLACK REACTED WITH DIAZONIUM SALTS AND PRODUCTS CABOT CORP (US) 2006-03-29 EP disclosed
US-20050034629-A1 In absence of exterior applies electrical current; wear resistance BELMONT JAMES A (US) 2005-02-17 US disclosed
US-6740151-B2 IN THE ABSENCE OF AN EXTERNALLY APPLIED ELECTRIC CURRENT SUFFICIENT TO REDUCE THE DIAZONIUM SALT AND ATTACH AN ORGANIC GROUP; IMPROVED ABRASION RESISTANCE. CABOT CORPORATION 2004-05-25 US disclosed
US-20030095914-A1 In the absence of an externally applied electric current sufficient to reduce the diazonium salt and attach an organic group; improved abrasion resistance. BELMONT JAMES A (US) 2003-05-22 US disclosed
EP-0960136-B1 THE USE OF MODIFIED CARBON BLACK IN GAS-PHASE POLYMERIZATIONS CABOT CORP (US) 2003-04-16 EP disclosed
US-5919855-A SOLVENT-FREE; BULK POLYMERIZATION CABOT CORPORATION (US) 1999-07-06 US disclosed
US-5900029-A COLORING FIBER OR TEXTILE CABOT CORPORATION (US) 1999-05-04 US disclosed
US-5851280-A Reaction of carbon black with diazonium salts, resultant carbon black products and their uses CABOT CORPORATION (US) 1998-12-22 US disclosed
EP-0799283-B1 CARBON BLACK PRODUCTS FOR COLORING MINERAL BINDERS CABOT CORP (US) 1998-09-16 EP disclosed
WO-1998034960-A1 THE USE OF MODIFIED CARBON BLACK IN GAS-PHASE POLYMERIZATIONS CABOT CORPORATION (US) 1998-08-13 WO disclosed
EP-0799283-A1 CARBON BLACK PRODUCTS FOR COLORING MINERAL BINDERS CABOT CORPORATION (US) 1997-10-08 EP disclosed
EP-0799281-A1 CARBON BLACK REACTED WITH DIAZONIUM SALTS AND PRODUCTS CABOT CORPORATION (US) 1997-10-08 EP disclosed
US-5575845-A Carbon black products for coloring mineral binders CABOT CORPORATION (US) 1996-11-19 US disclosed
WO-1996018688-A1 CARBON BLACK REACTED WITH DIAZONIUM SALTS AND PRODUCTS CABOT CORPORATION (US) 1996-06-20 WO disclosed
WO-1996018689-A1 CARBON BLACK PRODUCTS FOR COLORING MINERAL BINDERS CABOT CORPORATION (US) 1996-06-20 WO disclosed