Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253850 | 0.91 | SCN9A (0.38) | ICMTCHEK1WEE1CSF1RSMN1; SMN2 | |
| SCHEMBL3252380 | 0.90 | CSF1R (0.43) | CHEK1WEE1CSF1RSMN1; SMN2NPC1 | |
| SCHEMBL3252050 | 0.90 | GAA (0.40) | ICMTCHEK1WEE1CSF1RNPC1 | |
| SCHEMBL3255332 | 0.89 | ADORA3 (0.40) | CHEK1WEE1CSF1RSMN1; SMN2NPC1 | |
| SCHEMBL3255505 | 0.88 | CHEK1 (0.39) | ICMTCHEK1WEE1CSF1RSMN1; SMN2 | |
| SCHEMBL3252205 | 0.86 | TTK (0.42) | CHEK1SMN1; SMN2HPGDALDH1A1KMT2A | |
| SCHEMBL3250925 | 0.86 | NR1H2 (0.38) | ICMTWEE1CSF1RSMN1; SMN2NPC1 | |
| SCHEMBL3254793 | 0.86 | HRH2 (0.40) | CHEK1WEE1CSF1RNPC1TYMS | |
| SCHEMBL3250516 | 0.86 | TUBB4A (0.36) | CSF1RSMN1; SMN2NPC1CLEC4MTYMS | |
| SCHEMBL3244660 | 0.86 | TYMS (0.37) | ICMTCHEK1WEE1CSF1RSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |