Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | NGFR | P08138 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253850 | 0.92 | SCN9A (0.38) | ADORA3ALDH1A1KDM4ETP53NPC1 | |
| SCHEMBL3249476 | 0.89 | ICMT (0.37) | ADORA3ALDH1A1KDM4ETP53NPC1 | |
| SCHEMBL3245727 | 0.87 | GABRA1 (0.50) | ALDH1A1TP53NPC1MAPTRAB9A | |
| SCHEMBL3248921 | 0.87 | ALDH1A1 (0.41) | ALDH1A1KDM4ETP53MAPTSMN1; SMN2 | |
| SCHEMBL3252529 | 0.87 | ALDH1A1 (0.47) | ALDH1A1KDM4ETP53NPC1GAA | |
| SCHEMBL3250516 | 0.87 | TUBB4A (0.36) | ADORA3ALDH1A1KDM4ETP53NPC1 | |
| SCHEMBL3250557 | 0.85 | MAPT (0.41) | ALDH1A1KDM4ETP53MAPTHPGD | |
| SCHEMBL3250586 | 0.85 | HSD17B10 (0.37) | ALDH1A1KDM4ETP53GAARAB9A | |
| SCHEMBL3243057 | 0.85 | CHEK1 (0.37) | ADORA3ALDH1A1KDM4ETP53HPGD | |
| SCHEMBL3250430 | 0.84 | HSD17B10 (0.45) | ALDH1A1KDM4ETP53NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |