Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249811 | 0.86 | NOS3 (0.44) | XIAPBIRC2MAPTKDM4EALDH1A1 | |
| SCHEMBL1099019 | 0.81 | CACNA1C (0.51) | XIAPBIRC2MAPTKDM4EALDH1A1 | |
| SCHEMBL12820608 | 0.76 | FABP1 (0.55) | KDM4EALDH1A1MEN1KMT2ACXCR4 | |
| SCHEMBL8396192 | 0.75 | TLR8 (0.58) | XIAPBIRC2MAPTKDM4EALDH1A1 | |
| SCHEMBL690670 | 0.74 | — | — | |
| SCHEMBL9299788 | 0.74 | TLR8 (0.53) | XIAPBIRC2MAPTKDM4E | |
| SCHEMBL28799274 | 0.72 | APP (0.48) | KDM4EALDH1A1KCNH2HSD17B10NPC1 | |
| SCHEMBL16790977 | 0.72 | HRH3 (0.43) | XIAPBIRC2MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL16766687 | 0.70 | ALDH1A1 (0.44) | XIAPBIRC2MAPTKDM4EALDH1A1 | |
| SCHEMBL22011153 | 0.70 | HRH4 (0.40) | XIAPBIRC2MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513420-B2 | Amino-naphthyridine derivatives | Mazik, Monika (DE) | 2013-08-20 | — | — | US | disclosed |
| EP-2139889-B1 | AMINO-NAPHTHYRIDINE DERIVATIVES | TECH UNI CAROLO WILHELMINA ZU BRAUNSCHWEIG (DE) | 2012-12-19 | — | — | EP | disclosed |
| US-20100113505-A1 | AMINO-NAPHTHYRIDINE DERIVATIVES | MAZIK, MONIKA (DE) | 2010-05-06 | — | — | US | disclosed |
| EP-2139889-A1 | AMINO-NAPHTHYRIDINE DERIVATIVES | Technische Universität Carolo-Wilhelmina zu Braunschweig (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008113558-A1 | AMINO-NAPHTHYRIDINE DERIVATIVES | Technische Universität Carolo Wilhelmina Zu Braunschweig (DE) | 2008-09-25 | — | — | WO | disclosed |
| EP-1972627-A1 | Amino-napthyridine derivatives | Technische Universität Carolo-Wilhelmina zu Braunschweig (DE) | 2008-09-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113505-A1 | AMINO-NAPHTHYRIDINE DERIVATIVES | DNPEP, AADAT, AAAS | XIAP 2352/4885BIRC2 1144/4885MAPT 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.