Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252380 | 0.87 | CSF1R (0.43) | NPC1MEN1KMT2AHCRTR1RAB9A | |
| SCHEMBL3253850 | 0.86 | SCN9A (0.38) | NPC1MEN1KMT2ARAB9AJAK2 | |
| SCHEMBL3249865 | 0.85 | KDM4E (0.40) | NPC1MEN1KMT2ARAB9AMMP2 | |
| SCHEMBL3250692 | 0.85 | HPGD (0.34) | NPC1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL3252050 | 0.85 | GAA (0.40) | NPC1MEN1KMT2AJAK2JAK3 | |
| SCHEMBL3247669 | 0.84 | JAK2 (0.48) | CCNCCDK8NPC1MEN1KMT2A | |
| SCHEMBL3249647 | 0.84 | CHEK1 (0.37) | NPC1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL3249476 | 0.84 | ICMT (0.37) | NPC1MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL3243041 | 0.84 | WEE1 (0.38) | NPC1MEN1KMT2APTGS2JAK2 | |
| SCHEMBL3255505 | 0.83 | CHEK1 (0.39) | NPC1MEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |