Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250995 | 0.91 | PKM (0.34) | PKMALDH1A1MAPTHPGDLMNA | |
| SCHEMBL3251623 | 0.88 | ALDH1A1 (0.36) | PKMHTTMEN1KMT2AMCOLN3 | |
| SCHEMBL3255160 | 0.86 | MAPT (0.38) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL3245465 | 0.82 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL3252606 | 0.82 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL3254901 | 0.81 | KDM4E (0.38) | HTTMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3247132 | 0.81 | PKM (0.39) | PKMHTTMEN1KMT2AMCOLN3 | |
| SCHEMBL3251021 | 0.80 | MAPT (0.32) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL3249412 | 0.80 | — | — | |
| SCHEMBL3251355 | 0.80 | ALDH1A1 (0.37) | MEN1KMT2AL3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |