Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.55 |
| ▸ | LDHA | P00338 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9563030 | 0.84 | IDO1 (0.56) | IDO1NOTUMCYP2D6 | |
| SCHEMBL13710416 | 0.81 | SCN9A (0.48) | IDO1LDHAALPLCYP2A6HPGD | |
| SCHEMBL16964003 | 0.78 | KDM4E (0.49) | IDO1HSP90AA1HSP90AB1KMT2AMEN1 | |
| SCHEMBL11624658 | 0.77 | IDO1 (0.35) | IDO1HSP90AA1HSP90AB1CYP2A6SMN1; SMN2 | |
| SCHEMBL3846339 | 0.76 | ALPL (0.49) | IDO1ALPLHSP90AA1HSP90AB1KMT2A | |
| SCHEMBL30589021 | 0.76 | NISCH (0.42) | ALPLHPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27596511 | 0.76 | NISCH (0.42) | ALPLHPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11624239 | 0.76 | IDO1 (0.56) | IDO1ALPLHPGDSMN1; SMN2KMT2A | |
| SCHEMBL674356 | 0.76 | NISCH (0.42) | ALPLHPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1176838 | 0.75 | METAP2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833477-B1 | PYRAZOLO-HETEROARYL COMPOUNDS USEFUL TO TREAT TNF-ALPHA AND IL-1 MEDIATED DISEASES | NOVARTIS AG (CH) | 2010-06-02 | — | — | EP | claimed |
| CN-101076333-A | Pyrazolo-heteroaryl compounds useful to treat TNF-alpha and IL-1 mediated diseases | NOVARTIS AG (CH) | 2007-11-21 | — | — | CN | claimed |
| CN-112079780-A | Bipyrazole compound and preparation method thereof | 怀化学院 | 2020-12-15 | — | — | CN | disclosed |
| CN-109438354-A | A kind of preparation method of high-purity pyraclostrobin | 新沂市永诚化工有限公司 | 2019-03-08 | — | — | CN | disclosed |
| CN-106117143-B | A kind of preparation method of pyraclostrobin | 青岛瀚生生物科技股份有限公司 | 2019-01-08 | — | — | CN | disclosed |
| EP-2793880-A1 | HETEROARYLS AND USES THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013096630-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013096630-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | WO | disclosed |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| WO-2005121107-A1 | PYRAZOLO PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | disclosed |
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |
| CN-1050834-C | Fungicidal compositions for protecting plants against fungal diseases and uses thereof | RHONE POULENC AGROCHIMIE (FR) | 2000-03-29 | — | — | CN | disclosed |
| US-5663119-A | FOR USE IN AGRICULTURE | RHONE-POULENC AGROCHIMIE (FR) | 1997-09-02 | — | — | US | disclosed |
| CN-1131151-A | Method for preparation of 3-phenyl pyrazole derivant | RHONE POULENC AGROCHIMIE (FR) | 1996-09-18 | — | — | CN | disclosed |
| US-5523280-A | TREATING PLANT DISEASES | RHONE-POULENC AGROCHIMIE (FR) | 1996-06-04 | — | — | US | disclosed |
| EP-0538156-A1 | Fungicidal phenylpyrazoles | RHONE-POULENC AGROCHIMIE (FR) | 1993-04-21 | — | — | EP | disclosed |
| US-4072498-A | HERBICIDES | THE UPJOHN COMPANY (US) | 1978-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | PIK3C2B, PI4KB, PIK3R4 | IDO1 2374/4885LDHA 3580/4885ALPL 3705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.