Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2871069 | 0.83 | MAPT (0.46) | OXTRNPC1RAB9AMAPTKDM4E | |
| SCHEMBL2943875 | 0.75 | S1PR1 (0.44) | MAPTSMN1; SMN2LMNA | |
| SCHEMBL2944777 | 0.75 | S1PR1 (0.44) | MAPTSMN1; SMN2LMNA | |
| SCHEMBL2871064 | 0.74 | OXTR (0.39) | OXTRNPC1RAB9AMAPTTHRB | |
| SCHEMBL4518245 | 0.71 | S1PR1 (0.50) | NPC1RAB9AMAPTTHRBKDM4E | |
| SCHEMBL3258642 | 0.71 | ALDH1A1 (0.41) | NPC1RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL2941558 | 0.70 | TRPV1 (0.44) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4362063 | 0.69 | MAPT (0.62) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL2872160 | 0.67 | S1PR1 (0.47) | NPC1RAB9AMAPTTHRBKDM4E | |
| SCHEMBL14136973 | 0.66 | PTGES (0.40) | NPC1RAB9ADGAT1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747196-B1 | SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS INC (US) | 2010-02-10 | — | — | EP | claimed |