Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255401 | 0.87 | P2RX7 (0.39) | GAAALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL3255382 | 0.86 | CYP1A2 (0.37) | GAAALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL3256042 | 0.86 | P2RX7 (0.39) | GAAALDH1A1RAB9AP2RX7FFAR1 | |
| SCHEMBL3256647 | 0.84 | P2RX7 (0.34) | GAARAB9AP2RX7TP53FFAR4 | |
| SCHEMBL3258301 | 0.81 | GAA (0.38) | GAAALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL3256107 | 0.81 | KMT2A (0.39) | ALDH1A1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL3254057 | 0.81 | TP53 (0.42) | GAARAB9AMEN1KMT2AP2RX7 | |
| SCHEMBL3254884 | 0.81 | SIGMAR1 (0.35) | GAAALDH1A1TP53SIGMAR1PPARG | |
| SCHEMBL3255278 | 0.81 | SIGMAR1 (0.35) | GAAMEN1KMT2AP2RX7TP53 | |
| SCHEMBL3258687 | 0.80 | GPBAR1 (0.39) | GAAKMT2AKDM1ASIGMAR1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |