Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HRAS | P01112 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10131759 | 0.90 | DCTPP1 (0.40) | CNR1CNR2DCTPP1GSK3BQPCT | |
| SCHEMBL3256198 | 0.86 | MAPT (0.37) | GSK3BQPCTPLA2G2AALDH1A1LMNA | |
| SCHEMBL707715 | 0.86 | ALDH1A1 (0.43) | GSK3BQPCTHSP90AA1SMN1; SMN2PDE7A | |
| SCHEMBL711655 | 0.86 | TP53 (0.38) | CNR1CNR2DCTPP1SMN1; SMN2PDE7A | |
| SCHEMBL711463 | 0.85 | DCTPP1 (0.39) | CNR1CNR2DCTPP1HSP90AA1HSP90AB1 | |
| SCHEMBL3258185 | 0.85 | RAB9A (0.37) | DCTPP1GSK3BQPCTHSP90AA1HSP90AB1 | |
| SCHEMBL917542 | 0.85 | SLC6A2 (0.38) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3263625 | 0.85 | TP53 (0.40) | CNR1CNR2DCTPP1SMN1; SMN2PDE7A | |
| SCHEMBL3248070 | 0.84 | RAB9A (0.36) | DCTPP1GSK3BQPCTSMN1; SMN2PDE7A | |
| SCHEMBL13356967 | 0.83 | SLC6A2 (0.45) | CNR1CNR2PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585727-B1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | ORGANON NV (NL) | 2010-05-26 | — | — | EP | claimed |
| US-20060128722-A1 | Indoles useful in the treatment of androgen-receptor related diseases | AKZO NOBEL N.V. (NL) | 2006-06-15 | — | — | US | claimed |
| US-8124647-B2 | Non-steroidal androgens compounds | N.V. ORGANON (NL) | 2012-02-28 | — | — | US | disclosed |
| US-8124647-B2 | Non-steroidal androgens compounds | N.V. ORGANON (NL) | 2012-02-28 | — | — | US | disclosed |
| US-8124647-B2 | Non-steroidal androgens compounds | N.V. ORGANON (NL) | 2012-02-28 | — | — | US | disclosed |
| US-20110065768-A1 | NON-STEROIDAL ANDROGENS COMPOUNDS | MERCK SHARP & DOHME B.V. (NL) | 2011-03-17 | — | — | US | disclosed |
| US-20110065768-A1 | NON-STEROIDAL ANDROGENS COMPOUNDS | MERCK SHARP & DOHME B.V. (NL) | 2011-03-17 | — | — | US | disclosed |
| US-20110065768-A1 | NON-STEROIDAL ANDROGENS COMPOUNDS | MERCK SHARP & DOHME B.V. (NL) | 2011-03-17 | — | — | US | disclosed |
| US-7795280-B2 | Indoles useful in the treatment of androgen-receptor related diseases | N.V. ORGANON (NL) | 2010-09-14 | — | — | US | disclosed |
| US-7795280-B2 | Indoles useful in the treatment of androgen-receptor related diseases | N.V. ORGANON (NL) | 2010-09-14 | — | — | US | disclosed |
| US-7795280-B2 | Indoles useful in the treatment of androgen-receptor related diseases | N.V. ORGANON (NL) | 2010-09-14 | — | — | US | disclosed |
| EP-1585727-B1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | ORGANON NV (NL) | 2010-05-26 | — | — | EP | disclosed |
| US-20060128722-A1 | Indoles useful in the treatment of androgen-receptor related diseases | AKZO NOBEL N.V. (NL) | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065768-A1 | NON-STEROIDAL ANDROGENS COMPOUNDS | AR, NR5A1, SHBG | CNR1 246/4885CNR2 446/4885DCTPP1 4604/4885 |
| US-20060128722-A1 | Indoles useful in the treatment of androgen-receptor related diseases | AR, NR5A1, SHBG | CNR1 97/4885CNR2 158/4885DCTPP1 4288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.