SCHEMBL3256455

SCHEMBL3256455

O=C(C=Cc1ccccc1)OC(=O)C=Cc1ccccc1[N+](=O)[O-]

nearest known ligand 0.72

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.72
KMT2A Q03164 3/20 0.72
MAPT P10636 5/20 0.68
BACE1 P56817 1/20 0.63
MAOB P27338 1/20 0.62
ALDH1A1 P00352 7/20 0.62
LMNA P02545 3/20 0.61
RAB9A P51151 3/20 0.58
NPC1 O15118 2/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
KDM4E B2RXH2 1/20 0.58
NFKB1 P19838 1/20 0.58
NFKB2 Q00653 1/20 0.58
RELA Q04206 1/20 0.58
STAT3 P40763 1/20 0.57
ATM Q13315 2/20 0.53
HSP90AA1 P07900 1/20 0.53
AR P10275 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3256450 0.94 MEN1 (0.75) MEN1KMT2AMAPTBACE1MAOB
SCHEMBL3256449 0.94 MEN1 (0.75) MEN1KMT2AMAPTBACE1MAOB
SCHEMBL10768314 0.83 KMT2A (0.64) MEN1KMT2AMAPTBACE1MAOB
SCHEMBL6677087 0.82 MEN1 (0.71) MEN1KMT2AMAPTMAOBALDH1A1
SCHEMBL1019784 0.82 MEN1 (0.71) MEN1KMT2AMAPTMAOBALDH1A1
SCHEMBL2687117 0.82 MEN1 (0.71) MEN1KMT2AMAPTMAOBALDH1A1
SCHEMBL820084 0.81 MAPT (1.00) MEN1KMT2AMAPTBACE1MAOB
SCHEMBL10673342 0.81 MAPT (1.00) MEN1KMT2AMAPTBACE1MAOB
SCHEMBL42323 0.81 MAPT (1.00) MEN1KMT2AMAPTBACE1MAOB
SCHEMBL3295983 0.81 MAPT (1.00) MEN1KMT2AMAPTBACE1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110627832-A Preparation method for synthesizing tenofovir alafenamide by oxidation method 江西农业大学 2019-12-31 CN claimed
CN-110627832-A Preparation method for synthesizing tenofovir alafenamide by oxidation method 江西农业大学 2019-12-31 CN disclosed
US-7727434-B2 Membranes and methods of treating membranes GENERAL ELECTRIC COMPANY (US) 2010-06-01 US disclosed
EP-1438352-B1 LOW COLOR, LOW SODIUM BENZOXAZINONE UV ABSORBERS AND PROCESS FOR MAKING SAME CYTEC TECH CORP (US) 2010-05-26 EP disclosed
US-20070039874-A1 Membranes and methods of treating membranes GENERAL ELECTRIC COMPANY 2007-02-22 US disclosed
US-6774232-B2 FOR USE IN HIGH TRANSPARENCY APPLICATIONS; TO PREVENT DEGRADATION CAUSED BY SUNLIGHT AND OTHER SOURCES OF ULTRAVIOLET (UV) RADIATION OF POLYMERIC MATERIALS CYTEC TECHNOLOGY CORP. 2004-08-10 US disclosed
EP-1438352-A1 LOW COLOR, LOW SODIUM BENZOXAZINONE UV ABSORBERS AND PROCESS FOR MAKING SAME Cytec Technology Corp. (US) 2004-07-21 EP disclosed
US-20030096889-A1 Low color, low sodium benzoxazinone UV absorbers and process for making same CYTEC TECHNOLOGY CORP. 2003-05-22 US disclosed
WO-2003035735-A1 LOW COLOR, LOW SODIUM BENZOXAZINONE UV ABSORBERS AND PROCESS FOR MAKING SAME CYTEC TECHNOLOGY CORP. (US) 2003-05-01 WO disclosed
US-3989698-A ACYLATION, TERTIARY AMINE CATALYST, ISATOIC ANHYDRIDE THE SHERWIN-WILLIAMS COMPANY (US) 1976-11-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030096889-A1 Low color, low sodium benzoxazinone UV absorbers and process for making same XDH, SI, CA4 MEN1 3590/4885KMT2A 2104/4885MAPT 2774/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.