Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8592641 | 0.83 | SLC18A3 (0.39) | KMT2ASLC18A3 | |
| SCHEMBL8712010 | 0.69 | CYP1A1 (0.38) | KMT2ASLC18A3HRH3 | |
| SCHEMBL8863923 | 0.65 | CHRNA7 (0.58) | CHRNA7SLC18A3 | |
| SCHEMBL8707234 | 0.62 | HRH3 (0.37) | HRH3 | |
| SCHEMBL8921096 | 0.61 | ALDH1A1 (0.35) | CHRNA7SLC18A3HRH3 | |
| SCHEMBL8574139 | 0.61 | CHRNA7 (0.50) | CHRNA7 | |
| SCHEMBL8923497 | 0.61 | CNR1 (0.32) | KMT2ASLC18A3 | |
| SCHEMBL9513647 | 0.59 | ALOX5 (0.40) | SLC18A3 | |
| SCHEMBL8864168 | 0.58 | CHRNA7 (0.58) | CHRNA7SLC18A3 | |
| SCHEMBL27716094 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7667040-B2 | Azacyclic ethynyl derivatives | NEUROSEARCH A/S (DK) | 2010-02-23 | — | — | US | disclosed |
| US-20080188519-A1 | Novel azacyclic ethynyl derivatives | ANIONA APS (DK) | 2008-08-07 | — | — | US | disclosed |
| EP-1506205-B1 | NOVEL AZACYCLIC ETHYNYL DERIVATIVES | NEUROSEARCH AS (DK) | 2008-07-16 | — | — | EP | disclosed |
| US-7378526-B2 | Azacyclic ethynyl derivatives | NEUROSEARCH A/S (DK) | 2008-05-27 | — | — | US | disclosed |
| US-20050171078-A1 | Novel azacyclic ethynyl derivatives | NEUROSEARCH (DK) | 2005-08-04 | — | — | US | disclosed |
| EP-1506205-A2 | NOVEL AZACYCLIC ETHYNYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003094830-A2 | NOVEL AZACYCLIC ETHYNYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171078-A1 | Novel azacyclic ethynyl derivatives | CHRNA6, CHRNA5, CHRNA10 | ALPL 3097/4885ALPI 2823/4885ALPG 3492/4885 |
| US-20080188519-A1 | Novel azacyclic ethynyl derivatives | CHRNA6, CHRNA10, CHRNA5 | ALPL 2739/4885ALPI 2454/4885ALPG 2930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.