Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.84 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1079321 | 0.92 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL125188 | 0.92 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL30812783 | 0.92 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL597672 | 0.92 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL2509 | 0.92 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL3409457 | 0.92 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL30307036 | 0.92 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL30671620 | 0.92 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| Benzene SCHEMBL9751882 | 0.92 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6LMNA | |
| SCHEMBL9871011 | 0.89 | TSHR (0.94) | TSHRSMN1; SMN2POLBCYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112130416-B | Photoetching material, display substrate, manufacturing method of display substrate and display panel | 北京京东方技术开发有限公司 | 2024-02-13 | — | — | CN | claimed |
| CN-1977081-A | Product for use in papermaking and preparation thereof | CIBA SC HOLDING AG (CH) | 2007-06-06 | — | — | CN | claimed |
| CN-112130416-B | Photoetching material, display substrate, manufacturing method of display substrate and display panel | 北京京东方技术开发有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-112130416-A | Photoetching material, display substrate, manufacturing method of display substrate and display panel | 北京京东方技术开发有限公司 | 2020-12-25 | — | — | CN | disclosed |
| CN-104788312-B | Method for preparing vinyl acetate from ethylidene diacetate through pyrolysis | 华东理工大学 | 2017-01-18 | — | — | CN | disclosed |
| CN-105902551-A | Drug therapy for preventing or treating glaucoma | 兴和株式会社 | 2016-08-31 | — | — | CN | disclosed |
| CN-102666753-B | Anti fogging coating composite | NOF CORP. (JP) | 2016-04-13 | — | — | CN | disclosed |
| CN-104788312-A | Method for preparing vinyl acetate from ethylidene diacetate through pyrolysis | UNIV EAST CHINA SCIENCE & TECH | 2015-07-22 | — | — | CN | disclosed |
| CN-103338772-A | Pharmacotherapy for preventing or treating glaucoma | KOWA CO | 2013-10-02 | — | — | CN | disclosed |
| US-7682487-B2 | Product for use in papermaking and preparation thereof | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2010-03-23 | — | — | US | disclosed |
| US-20080017340-A1 | Product For Use In Papermaking And Preparation Thereof | CIBA SPECIALTY CHEMICALS CORP. | 2008-01-24 | — | — | US | disclosed |
| CN-1507319-A | Insecticidal composition having improved storage stability | ��˹��ŵ�� | 2004-06-23 | — | — | CN | disclosed |
| EP-0763577-A1 | Fast drying, bleed-free ink-jet ink compositions | Hewlett-Packard Company (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0302793-B1 | Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI ELF (FR) | 1993-12-15 | — | — | EP | disclosed |
| US-5215988-A | Treating angina, hypertension, arrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-06-01 | — | — | US | disclosed |
| US-5147878-A | Hypotensive, antiarrhythmia agents | SANOFI (FR) | 1992-09-15 | — | — | US | disclosed |
| US-5017579-A | Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure | SANOFI (FR) | 1991-05-21 | — | — | US | disclosed |
| US-4994474-A | Hypotensive agents | SANOFI (FR) | 1991-02-19 | — | — | US | disclosed |
| EP-0302792-A2 | Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |
| EP-0302793-A2 | Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | ELF SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |