SCHEMBL3262138

SCHEMBL3262138

C[SiH](C)Oc1[c]cccc1C(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.33
ALDH1A1 P00352 1/20 0.32
TSHR P16473 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8477975 0.80 ALDH1A1 (0.32) ALDH1A1TSHRTDP1
SCHEMBL4634623 0.79 CA2 (0.37) CA2ALDH1A1TSHRTDP1
SCHEMBL7200096 0.78 CA2 (0.32) CA2
SCHEMBL7197680 0.77 CA2 (0.32) CA2
SCHEMBL16956107 0.74 CA2 (0.33) CA2ALDH1A1TSHRTDP1
SCHEMBL17046259 0.74 CA2 (0.33) CA2ALDH1A1TSHRTDP1
SCHEMBL5632254 0.73 LTA4H (0.38) CA2ALDH1A1TSHRTDP1
SCHEMBL8173016 0.72 RXRA (0.42) CA2ALDH1A1TSHRTDP1
SCHEMBL5791366 0.71 CA2 (0.31) CA2ALDH1A1TSHRTDP1
SCHEMBL7197893 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6509426-B2 Dichloro(1,1'-dimethylsilylenebis(2-methyl-4-(4-methoxyphenyl) -4H-azulenyl))zirconium, for example; can produce polyolefin with high molecular weight and high melting point for extrusion or injection moldability JAPAN POLYCHEM CORPORATION (JP) 2003-01-21 US claimed
WO-2010024365-A1 AMIDE COMPOUNDS AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-03-04 WO disclosed
EP-1112274-B1 CHEMILUMINESCENT 1,2-DIOXETANES GIRI BRIJ P (US) 2009-12-09 EP disclosed
EP-2048140-A1 Deuterated chemiluminescent 1,2-dioxetanes Giri, Brij P. (US) 2009-04-15 EP disclosed
EP-1453822-A4 DEUTERIUM-BASED CHEMILUMINESCENT 1,2-DIOXETANES GIRI BRIJ P (US) 2004-11-24 EP disclosed
EP-1453822-A2 DEUTERIUM-BASED CHEMILUMINESCENT 1,2-DIOXETANES Giri, Brij P. (US) 2004-09-08 EP disclosed
WO-2003054506-A2 DEUTERIUM-BASED CHEMILUMINESCENT 1,2-DIOXETANES GIRI BRIJ PAL (US) 2003-07-03 WO disclosed
US-5869698-A 1,2-dioxetane compounds as chemiluminescent labels for organic and biological molecules BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) 1999-02-09 US disclosed
US-5770743-A IMMUNOASSAY BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) 1998-06-23 US disclosed
EP-0473984-A1 1,2-Dioxetane compounds as chemiluminescent labels for organic and biological molecules THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) 1992-03-11 EP disclosed