Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monomethyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 known ✓ | Q14145 | 1/20 | 0.59 |
| ▸ | HCAR2 | Q8TDS4 | 10/20 | 0.77 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monomethyl Fumarate SCHEMBL9797085 | 1.00 | HCAR2 (0.77) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL6346060 | 0.89 | HCAR2 (0.74) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL22266105 | 0.88 | HCAR2 (0.81) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL28412434 | 0.88 | HCAR2 (0.81) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL5607800 | 0.88 | HCAR2 (0.90) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL5607806 | 0.88 | HCAR2 (0.90) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL25280962 | 0.88 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Dimethyl Fumarate SCHEMBL15573963 | 0.88 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Dimethyl Fumarate SCHEMBL15573962 | 0.88 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL60132 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5255052-A | — | — | None | — | — | JP | disclosed |
| US-8821845-B2 | Concentrated ingredient for treating and/or modifying surfaces, and use thereof in cosmetic compositions | RHODIA CHIMIE (FR) | 2014-09-02 | — | — | US | disclosed |
| US-8680038-B2 | Copolymer containing zwitterionic units and other units, composition comprising the copolymer, and use | RHODIA OPERATIONS (FR) | 2014-03-25 | — | — | US | disclosed |
| US-8343520-B2 | For treating skin or hair; stability, transparency | RHODIA CHIMIE (FR) | 2013-01-01 | — | — | US | disclosed |
| US-20120183590-A1 | Cosmetic Composition Comprising An Ampholytic Copolymer | RHODIA OPERATIONS (FR) | 2012-07-19 | — | — | US | disclosed |
| US-7846423-B2 | Cosmetic composition comprising a block copolymer | RHODIA CHIMIE (FR) | 2010-12-07 | — | — | US | disclosed |
| US-20100061956-A1 | COSMETIC COMPOSITION COMPRISING AN AMPHOLYTIC COPOLYMER | RHODIA CHIMIE (FR) | 2010-03-11 | — | — | US | disclosed |
| US-20090304757-A1 | Cosmetic Compositions Comprising A Powdered Thermoplastic | RHODIA OPERATIONS (FR) | 2009-12-10 | — | — | US | disclosed |
| EP-1854843-B1 | Cosmetic composition comprising a block copolymer | RHODIA CHIMIE SA (FR) | 2009-09-09 | — | — | EP | disclosed |
| US-20090214608-A1 | POLYSACCHARIDE-BASED PRODUCTS WITH IMPROVED EASINESS OF USE, PROCESS TO MAKE THE SAME, AND APPLICATIONS OF THE SAME | RHODIA OPERATIONS (FR) | 2009-08-27 | — | — | US | disclosed |
| WO-2003050184-A1 | COSMETIC COMPOSITION COMPRISING A BLOCK COPOLYMER | RHODIA CHIMIE (FR) | 2003-06-19 | — | — | WO | disclosed |
| US-6509023-B1 | Mixture of trisiloxanes containing phenylalkyl or phenyl-alkenyl groups; emollient, vehicle and/or transfer resistance agent; skin, hair | Chimie, Rhodia (FR) | 2003-01-21 | — | — | US | disclosed |
| US-6030630-A | Cosmetic compositions for the hair or skin based on sulfone copolyesters with polyorganosiloxane units | RHODIA CHIMIE (FR) | 2000-02-29 | — | — | US | disclosed |
| US-5607812-A | CONTAINS /1/ALKALI PROCESSING ELEMENT WITH TERTIARY AMINE POLYMER AND SURFACE-ACTIVE OLIGOMER OR POLYMER AND /2/LIGHT SENSITIVE SILVER HALIDE ELEMENT WITH DYE IMAGE-FORMING SUBSTANCES AND DYE IMAGE-RECEIVING ELEMENTS OR LAYERS | FUJI PHOTO FILM CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| US-5447818-A | Developer solution containing polymer with pendant amine groups, high density transfer image | FUJI PHOTO FILM CO, LTD. (JP) | 1995-09-05 | — | — | US | disclosed |
| JP-H05255052-A | HAIR-DRESSING FORMULATION AND HAIR-DRESSING METHOD | DOW CORNING CORP | 1993-10-05 | — | — | JP | disclosed |
| US-4994363-A | Silver halide light-sensitive material containing a compound releasing a photographically useful group | FUJI PHOTO FILM CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| US-4939066-A | DEVELOPMENT INHIBITOR-RELEASING COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| US-4916047-A | POLYMERIC COMPOUND RELEASING USEFUL GROUP BY REDOX PROCESS TRIGGERED BY REDUCING AGENT | FUJI PHOTO FILM CO., LTD. (JP) | 1990-04-10 | — | — | US | disclosed |
| US-4265778-A | FATTY ACID SALT, INTERPOLYMER OF A MALEIC ANHYDRIDE OR ACID AND A VINYL LACTAM OR VINYL ETHER OR ESTER | COLGATE-PALMOLIVE COMPANY (US) | 1981-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100061956-A1 | COSMETIC COMPOSITION COMPRISING AN AMPHOLYTIC COPOLYMER | ABHD16A, CUTA, PSAP | KEAP1 4830/4885HCAR2 1690/4885NFE2L2 4816/4885 |
| US-20120183590-A1 | Cosmetic Composition Comprising An Ampholytic Copolymer | ABHD16A, CUTA, PSAP | KEAP1 4830/4885HCAR2 1690/4885NFE2L2 4816/4885 |
| US-20090304757-A1 | Cosmetic Compositions Comprising A Powdered Thermoplastic | KRT18, CUTA, LAGE3 | KEAP1 772/4885HCAR2 4855/4885NFE2L2 4045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.