Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31037319 | 1.00 | KDM4E (0.48) | KDM4ENPC1USP2ALDH1A1GLA | |
| SCHEMBL29002568 | 0.89 | KDM4E (0.51) | KDM4ENPC1USP2ALDH1A1GLA | |
| SCHEMBL19965243 | 0.80 | LPL (0.40) | KDM4ENPC1ALDH1A1MAPTHPGD | |
| SCHEMBL29964406 | 0.79 | PARG (0.41) | NPC1RAB9APARP1PRMT5WDR77 | |
| SCHEMBL27157743 | 0.78 | KDM4E (0.47) | KDM4EGAAPARP1PRMT5WDR77 | |
| SCHEMBL30041886 | 0.78 | KDM4E (0.47) | KDM4EGAAPARP1PRMT5WDR77 | |
| SCHEMBL15574354 | 0.77 | ALDH1A1 (0.49) | KDM4ENPC1ALDH1A1GLAGAA | |
| SCHEMBL30016751 | 0.77 | PARP1 (0.54) | ALDH1A1SMN1; SMN2PARP1TNKS2PRMT5 | |
| SCHEMBL393560 | 0.77 | PARP1 (0.54) | ALDH1A1SMN1; SMN2PARP1TNKS2PRMT5 | |
| SCHEMBL3262278 | 0.75 | IDO1 (0.45) | ALDH1A1PRMT5WDR77IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020366-A1 | AZABICYCLIC SUBSTITUTED 5-AMINOPYRAZOLES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010020366-A1 | AZABICYCLIC SUBSTITUTED 5-AMINOPYRAZOLES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-02-25 | — | — | WO | disclosed |