Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.45 |
| ▸ | HK1 | P19367 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | CCR9 | P51686 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284695 | 0.81 | TDP1 (0.51) | LMNAALDH1A1CYP1A2KCNA5KEAP1 | |
| SCHEMBL3186556 | 0.76 | CYP2C9 (0.51) | LMNAALDH1A1CYP1A2HSD17B10TSHR | |
| SCHEMBL3176961 | 0.76 | LMNA (0.55) | LMNAHTTALDH1A1HPGDHSD17B10 | |
| SCHEMBL3170331 | 0.74 | HTT (0.46) | LMNAHTTALDH1A1HPGDHSD17B10 | |
| SCHEMBL12220857 | 0.73 | LMNA (0.81) | LMNAHTTALDH1A1CYP1A2HPGD | |
| SCHEMBL27995 | 0.73 | ALDH1A1 (0.74) | LMNAHTTALDH1A1CYP1A2HPGD | |
| SCHEMBL9664772 | 0.72 | ALDH1A1 (0.44) | LMNAHTTALDH1A1SMN1; SMN2KEAP1 | |
| SCHEMBL7275199 | 0.72 | HTT (0.46) | LMNAHTTALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL3177473 | 0.71 | LMNA (0.58) | LMNAALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL3180328 | 0.71 | ALDH1A1 (0.52) | LMNAALDH1A1HPGDTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659272-B2 | CCR9 inhibitors and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-02-09 | — | — | US | claimed |
| EP-0516392-B1 | Naphthyridine derivatives as angiotensin II inhibitors | ASTRAZENECA AB (SE) | 2001-08-29 | — | — | EP | disclosed |
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0516392-A2 | Naphthyridine derivatives as angiotensin II inhibitors | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | disclosed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |