Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | BDKRB1 | P46663 | 8/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.58 |
| ▸ | METAP2 | P50579 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31305 | 0.90 | BDKRB1 (0.72) | ALDH1A1CYP1A2HPGDHSD17B10LMNA | |
| SCHEMBL28289991 | 0.89 | BDKRB1 (0.74) | ALDH1A1CYP1A2HPGDHSD17B10LMNA | |
| SCHEMBL12220857 | 0.89 | LMNA (0.81) | ALDH1A1CYP1A2HPGDHSD17B10LMNA | |
| SCHEMBL11501459 | 0.88 | LMNA (0.69) | ALDH1A1CYP1A2HPGDHSD17B10LMNA | |
| SCHEMBL9069174 | 0.87 | ALDH1A1 (0.69) | ALDH1A1CYP1A2HPGDHSD17B10LMNA | |
| SCHEMBL3041146 | 0.87 | BDKRB1 (0.70) | ALDH1A1CYP1A2HPGDHSD17B10LMNA | |
| SCHEMBL1688339 | 0.87 | METAP2 (0.71) | ALDH1A1CYP1A2HPGDHSD17B10LMNA | |
| SCHEMBL5095180 | 0.86 | BDKRB1 (0.68) | ALDH1A1CYP1A2HPGDHSD17B10LMNA | |
| SCHEMBL2534648 | 0.86 | BDKRB1 (0.73) | ALDH1A1CYP1A2HPGDHSD17B10LMNA | |
| SCHEMBL29879363 | 0.84 | LMNA (0.59) | ALDH1A1CYP1A2HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402310-A1 | CCR9 inhibitors and methods of use thereof | Millennium Pharmaceuticals, Inc. (US) | 2012-01-04 | — | — | EP | claimed |
| EP-2399903-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2011-12-28 | — | — | EP | claimed |
| US-20100324093-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-12-23 | — | — | US | claimed |
| US-7741519-B2 | Bis-aryl sulfonamides | CHEMOCENTRYX, INC. (US) | 2010-06-22 | — | — | US | claimed |
| US-20100093802-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | MILLENNNIUM PHARMACEUTICALS, INC. (US) | 2010-04-15 | — | — | US | claimed |
| US-20080261966-A1 | BIS-ARYL SULFONAMIDES | UNGASHE SOLOMON | 2008-10-23 | — | — | US | claimed |
| US-7227035-B2 | Bis-aryl sulfonamides | CHEMOCENTRYX (US) | 2007-06-05 | — | — | US | claimed |
| US-20070066823-A1 | CCR9 inhibitors and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2007-03-22 | — | — | US | claimed |
| US-20060167251-A1 | CCR9 inhibitors and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2006-07-27 | — | — | US | claimed |
| EP-1507756-A4 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | MILLENNIUM PHARM INC (US) | 2006-03-15 | — | — | EP | claimed |
| JP-2005526857-A | — | — | 2005-09-08 | — | — | JP | claimed |
| EP-1507756-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2005-02-23 | — | — | EP | claimed |
| WO-2003099773-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-12-04 | — | — | WO | claimed |
| US-20160068479-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | MILLENNIUM PHARMECEUTICALS INC (US) | 2016-03-10 | — | — | US | disclosed |
| US-20160068479-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | MILLENNIUM PHARMECEUTICALS INC (US) | 2016-03-10 | — | — | US | disclosed |
| US-20160068479-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | MILLENNIUM PHARMECEUTICALS INC (US) | 2016-03-10 | — | — | US | disclosed |
| EP-0469984-B1 | N-sulfonyl-indoline derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1995-10-18 | — | — | EP | disclosed |
| EP-0469984-A2 | N-sulfonyl-indoline derivatives, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-02-05 | — | — | EP | disclosed |
| EP-0015214-B1 | DERIVATIVES OF SUBSTITUTED 2-BENZOYL GLYCINANILIDES, THEIR PREPARATION AND THEIR USE IN ANXIOLYTIC MEDICAMENTS | PIERRE FABRE S.A. (FR) | 1982-01-27 | — | — | EP | disclosed |
| EP-0015214-A1 | Derivatives of substituted 2-benzoyl glycinanilides, their preparation and their use in anxiolytic medicaments | PIERRE FABRE S.A. (FR) | 1980-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093802-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | CCR9, CCR1, CCR4 | ALDH1A1 2607/4885CYP1A2 3457/4885HPGD 3695/4885 |
| US-20060167251-A1 | CCR9 inhibitors and methods of use thereof | CCR9, CCR1, CCR4 | ALDH1A1 2607/4885CYP1A2 3457/4885HPGD 3695/4885 |
| US-20160068479-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | CCR9, CCR1, CCR4 | ALDH1A1 2607/4885CYP1A2 3457/4885HPGD 3695/4885 |
| US-20080261966-A1 | BIS-ARYL SULFONAMIDES | CCR2, CXCR2, CCL2 | ALDH1A1 2054/4885CYP1A2 3096/4885HPGD 1424/4885 |
| US-20070066823-A1 | CCR9 inhibitors and methods of use thereof | CCR9, CCR1, CCR4 | ALDH1A1 2607/4885CYP1A2 3457/4885HPGD 3695/4885 |
| US-20100324093-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | CCR9, CCR1, CCR4 | ALDH1A1 2607/4885CYP1A2 3457/4885HPGD 3695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.