Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264465 | 1.00 | FAAH (0.34) | FAAHHRH3MEN1KMT2AKDM4E | |
| SCHEMBL3232200 | 1.00 | FAAH (0.34) | FAAHHRH3MEN1KMT2AKDM4E | |
| SCHEMBL3266879 | 1.00 | FAAH (0.34) | FAAHHRH3MEN1KMT2AKDM4E | |
| SCHEMBL3267302 | 0.89 | HRH3 (0.36) | FAAHHRH3MEN1KMT2AKDM4E | |
| SCHEMBL3264462 | 0.87 | FAAH (0.35) | FAAHHRH3MEN1KMT2AKDM4E | |
| SCHEMBL3264483 | 0.87 | FAAH (0.35) | FAAHHRH3MEN1KMT2AKDM4E | |
| SCHEMBL3266877 | 0.87 | FAAH (0.35) | FAAHHRH3MEN1KMT2AKDM4E | |
| SCHEMBL3232196 | 0.87 | FAAH (0.35) | FAAHHRH3MEN1KMT2AKDM4E | |
| SCHEMBL3267163 | 0.87 | EPHX2 (0.37) | FAAHMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3220898 | 0.86 | MTNR1B (0.39) | FAAHMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010026096-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | claimed |
| WO-2010026096-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |