Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265779 | 0.84 | KDM4E (0.46) | KDM4EGAALMNAMAPTTP53 | |
| SCHEMBL3265449 | 0.83 | KDM4E (0.44) | KDM4EGAASCN10ASMN1; SMN2LMNA | |
| SCHEMBL3266083 | 0.76 | CSGALNACT1 (0.51) | KDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL2297789 | 0.73 | KDM4E (0.47) | KDM4EGAASCN10AHDAC4SMPD1 | |
| SCHEMBL3265091 | 0.73 | KDM4E (0.47) | KDM4EGAASCN10AHDAC4SMPD1 | |
| SCHEMBL5314933 | 0.66 | HTT (0.50) | KDM4ESMN1; SMN2LMNAMAPTTP53 | |
| SCHEMBL2563085 | 0.66 | GAA (0.68) | KDM4EGAASMPD1LMNAMAPT | |
| SCHEMBL493052 | 0.65 | KDM4E (0.73) | KDM4EGAAHDAC4SMN1; SMN2LMNA | |
| SCHEMBL493495 | 0.65 | KDM4E (0.70) | KDM4EGAASMN1; SMN2LMNAMAPT | |
| SCHEMBL25003157 | 0.64 | GAA (0.69) | KDM4EGAASMPD1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010023609-A1 | OXAZOLE, OXADIAZOLE AND THIAZOLE DERIVATIVES AS DIACYLGLYCEROL ACYLTRANFERASE INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2010-03-04 | — | — | WO | disclosed |