Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265094 | 0.84 | KDM4E (0.52) | KDM4EGAALMNAMAPTPOLB | |
| SCHEMBL3265449 | 0.79 | KDM4E (0.44) | KDM4EGAALMNAMAPTNPC1 | |
| SCHEMBL2300388 | 0.75 | LMNA (0.45) | KDM4EGAALMNAMAPK1MAPT | |
| SCHEMBL3265775 | 0.75 | LMNA (0.45) | KDM4EGAALMNAMAPK1MAPT | |
| SCHEMBL3266083 | 0.73 | CSGALNACT1 (0.51) | KDM4ELMNAMAPTNPC1RAB9A | |
| SCHEMBL27912050 | 0.73 | LMNA (0.56) | LMNAMAPK1MAPTNPC1RAB9A | |
| SCHEMBL5328889 | 0.71 | MAPT (0.61) | LMNAMAPK1MAPTNPC1RAB9A | |
| SCHEMBL2296702 | 0.69 | HTT (0.62) | GAALMNAMAPTNPC1RAB9A | |
| SCHEMBL1053128 | 0.69 | MGLL (0.49) | GAALMNAMAPTNPC1RAB9A | |
| SCHEMBL3832953 | 0.67 | HDAC2 (0.59) | LMNAMAPK1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010023609-A1 | OXAZOLE, OXADIAZOLE AND THIAZOLE DERIVATIVES AS DIACYLGLYCEROL ACYLTRANFERASE INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2010-03-04 | — | — | WO | disclosed |