Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265220 | 0.76 | LMNA (0.37) | MMEACECHRM2CHRM1CHRM3 | |
| SCHEMBL27787074 | 0.64 | MAPT (0.56) | ALDH1A1MAPTKMT2ALMNAHPGD | |
| SCHEMBL17629532 | 0.63 | ALDH1A1 (0.37) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL4812296 | 0.63 | KMT2A (0.48) | ALDH1A1MAPTKMT2ALMNAHPGD | |
| SCHEMBL4733 | 0.62 | CYP1A2 (0.55) | ALDH1A1MAPTKMT2ALMNAHPGD | |
| SCHEMBL25423720 | 0.62 | ALDH1A1 (0.47) | ALDH1A1MAPTKMT2ALMNAHPGD | |
| SCHEMBL28394950 | 0.61 | ALDH1A1 (0.52) | CHRM2CHRM1CHRM3TAS2R14ALDH1A1 | |
| SCHEMBL15692219 | 0.61 | KMT2A (0.46) | MMEACETAS2R14ALDH1A1MAPT | |
| Benzene SCHEMBL29172594 | 0.61 | CYP4F2 (0.68) | ALDH1A1MAPTKMT2ALMNAHPGD | |
| SCHEMBL28020391 | 0.60 | MME (0.43) | MMEACEALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471024-B2 | Tetrahydrofuropyridones | MERCK SHARP & DOHME, CORP. (US) | 2013-06-25 | — | — | US | disclosed |
| EP-2257170-B1 | TETRAHYDROFUROPYRIDONES | MERCK SHARP & DOHME (US) | 2012-12-26 | — | — | EP | disclosed |
| US-20100331358-A1 | TETRAHYDROFUROPYRIDONES | MERCK SHARP & DOHME LLC | 2010-12-30 | — | — | US | disclosed |
| EP-2257170-A1 | TETRAHYDROFUROPYRIDONES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009108496-A1 | TETRAHYDROFUROPYRIDONES | MERCK & CO., INC. (US) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331358-A1 | TETRAHYDROFUROPYRIDONES | HIF1AN, EGLN3, HIF1A | MME 3335/4885ACE 2666/4885CHRM2 4883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.