Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | LPL | P06858 | 5/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24165087 | 0.82 | LTA4H (0.49) | LPLLIPGRECQLSMN1; SMN2LTA4H | |
| SCHEMBL5254853 | 0.82 | LPL (0.55) | ALDH1A1KDM4ELPLLIPGSMN1; SMN2 | |
| SCHEMBL429722 | 0.82 | LMNA (0.53) | ALDH1A1KDM4ELPLLIPGCA2 | |
| SCHEMBL17419098 | 0.82 | NPSR1 (0.44) | ALDH1A1KDM4ECYP2D6KMT2ANPSR1 | |
| SCHEMBL25420960 | 0.82 | LIPG (0.43) | LPLLIPGCA1CA2CA9 | |
| SCHEMBL3319981 | 0.82 | LPL (0.54) | ALDH1A1KDM4ELPLLIPGCA2 | |
| SCHEMBL1354581 | 0.82 | LPL (0.54) | ALDH1A1KDM4ECYP2D6LPLLIPG | |
| SCHEMBL13517081 | 0.81 | ROCK1 (0.48) | ALDH1A1KDM4ECYP2D6LPLLIPG | |
| SCHEMBL427977 | 0.80 | HRH3 (0.56) | ALDH1A1KDM4ECYP2D6LPLLIPG | |
| SCHEMBL2449062 | 0.80 | POLB (0.45) | ALDH1A1KDM4ECYP2D6CYP2C9LPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |