Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 2/20 | 0.53 |
| ▸ | CDC25B | P30305 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | CDC25A | P30304 | 1/20 | 0.46 |
| ▸ | CDC25C | P30307 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30445585 | 0.74 | ALDH1A1 (0.60) | MAPTKDM4EKMT2AHTTCASP3 | |
| SCHEMBL4835948 | 0.73 | CDC25B (0.51) | MAPTKDM4ESMN1; SMN2KMT2ARECQL | |
| SCHEMBL3328872 | 0.73 | MAPT (0.50) | MAPTKDM4ESMN1; SMN2KMT2AHTT | |
| SCHEMBL3293555 | 0.72 | KDM4E (0.51) | MAPTKDM4ESMN1; SMN2KMT2AHTT | |
| SCHEMBL11004551 | 0.72 | MAPT (0.68) | MAPTKDM4ESMN1; SMN2KMT2AHTT | |
| SCHEMBL28680301 | 0.72 | CASP3 (0.56) | MAPTKDM4ESMN1; SMN2KMT2AHTT | |
| SCHEMBL4745616 | 0.71 | ALDH1A1 (0.76) | MAPTKDM4ESMN1; SMN2KMT2AHTT | |
| SCHEMBL277672 | 0.70 | CDC25B (0.82) | MAPTKDM4EKMT2ACDC25BALDH1A1 | |
| SCHEMBL28216149 | 0.70 | KMT2A (0.52) | MAPTKDM4ESMN1; SMN2KMT2ACDC25B | |
| SCHEMBL6312871 | 0.69 | ALDH1A1 (0.56) | MAPTKDM4ESMN1; SMN2KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |