Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656072 | 0.78 | CES2 (0.50) | MAPTCYP1A2HPGDALOX12CYP2C19 | |
| SCHEMBL10544046 | 0.78 | NPC1 (0.53) | MAPTCYP1A2HPGDALOX12CYP2C19 | |
| SCHEMBL2915596 | 0.77 | CYP1A2 (0.57) | MAPTCYP1A2HPGDALOX12CYP2C19 | |
| SCHEMBL9395656 | 0.77 | ALDH1A1 (0.56) | MAPTHPGDCES2CES1MAOB | |
| SCHEMBL11822738 | 0.77 | ALDH1A1 (0.53) | MAPTCYP1A2HPGDALOX12CYP2C19 | |
| SCHEMBL11822730 | 0.77 | ALDH1A1 (0.53) | MAPTCYP1A2HPGDALOX12CYP2C19 | |
| SCHEMBL6998661 | 0.77 | MAPT (0.67) | MAPTCYP1A2HPGDALOX12CYP2C19 | |
| SCHEMBL6998663 | 0.77 | MAPT (0.67) | MAPTCYP1A2HPGDALOX12CYP2C19 | |
| Bromide SCHEMBL11813070 | 0.75 | ALDH1A1 (0.51) | MAPTCYP1A2HPGDALOX12CYP2C19 | |
| SCHEMBL3188558 | 0.75 | ALDH1A1 (0.51) | MAPTCYP1A2HPGDALOX12CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878723-B1 | N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide derivatives antagonists of the CB1 cannabinoids receptors | SANOFI AVENTIS (FR) | 2010-05-26 | — | — | EP | disclosed |
| EP-1878723-A1 | N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide derivatives antagonists of the CB1 cannabinoids receptors | Sanofi-Aventis (FR) | 2008-01-16 | — | — | EP | disclosed |