SCHEMBL32667418

SCHEMBL32667418

c1coc(-c2ccccc2CN2CCNCC2)c1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.51
OPRM1 P35372 3/20 0.49
OPRD1 P41143 3/20 0.49
MAPT P10636 3/20 0.49
SIGMAR1 Q99720 1/20 0.46
ALDH1A1 P00352 3/20 0.45
POLB P06746 1/20 0.45
MAPK1 P28482 1/20 0.45
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
OPRK1 P41145 1/20 0.40
HTR7 P34969 2/20 0.39
CXCR4 P61073 1/20 0.39
PIM1 P11309 1/20 0.39
HTR6 P50406 1/20 0.38
HCRTR1 O43613 1/20 0.38
HCRTR2 O43614 1/20 0.38
ADRA1A P35348 1/20 0.38
ADRA1B P35368 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32667408 0.79 LMNA (0.48) LMNASIGMAR1OPRK1HTR7CXCR4
SCHEMBL30616744 0.76 HTR7 (0.64) LMNASIGMAR1HTR7CXCR4HTR6
SCHEMBL2472212 0.76 HTR7 (0.64) LMNASIGMAR1HTR7CXCR4HTR6
SCHEMBL32667432 0.75 SIGMAR1 (0.56) MAPTSIGMAR1ALDH1A1POLBMEN1
SCHEMBL7097403 0.75 HTR7 (0.62) LMNASIGMAR1HTR7CXCR4HTR6
SCHEMBL7098276 0.74 LMNA (0.55) LMNAMAPTSIGMAR1ALDH1A1POLB
SCHEMBL7830202 0.74 HTR7 (0.58) LMNASIGMAR1ALDH1A1HTR7HTR6
SCHEMBL7102078 0.74 LMNA (0.55) LMNAOPRM1OPRD1MAPTSIGMAR1
SCHEMBL32667562 0.73 SIGMAR1 (0.42) LMNAOPRD1MAPTSIGMAR1ALDH1A1
SCHEMBL2909630 0.73 ALDH1A1 (0.62) LMNAMAPTSIGMAR1ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260028326-A1 COMPOUND BASED ON ISOINDOLINE-SUBSTITUTED GLUTARIMIDE BACKBONE AND USE THEREOF GLUETACS THERAPEUTICS SHANGHAI CO LTD (CN) 2026-01-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028326-A1 COMPOUND BASED ON ISOINDOLINE-SUBSTITUTED GLUTARIMIDE BACKBONE AND USE THEREOF CDR2, CYC1, CLN6 LMNA 66/4885OPRM1 412/4885OPRD1 254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.