Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | IL2 | P60568 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24345745 | 0.77 | CA12 (0.35) | MAPK1 | |
| SCHEMBL32669063 | 0.75 | MAPK1 (0.39) | NOTUMUSP7PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL32669097 | 0.75 | CA12 (0.39) | NOTUMPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL29183431 | 0.72 | ALDH1A1 (0.51) | NOTUMHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9259362 | 0.72 | ALOX15 (0.55) | MAPK1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL28128556 | 0.72 | NPC1 (0.50) | NOTUM | |
| SCHEMBL29183388 | 0.72 | NPC1 (0.48) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL15874209 | 0.72 | KDM4E (0.49) | NOTUM | |
| SCHEMBL7450038 | 0.72 | ALOX15 (0.53) | NOTUMMAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL15062653 | 0.71 | NPC1 (0.47) | MAPK1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260035358-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2026-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260035358-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | CRBN, WEE1, WEE2 | NOTUM 1387/4885USP7 298/4885PRKAB2 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.