SCHEMBL32669629

SCHEMBL32669629

CN(CC#CCc1ccccn1)C(=O)/C(C#N)=C(\O)c1cc(F)c(O)c(C#N)c1

nearest known ligand 0.34

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
COMT P21964 1/20 0.33
FTO Q9C0B1 1/20 0.33
MAPK1 P28482 1/20 0.33
CXCR3 P49682 1/20 0.33
NPC1 O15118 1/20 0.33
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33
MCL1 Q07820 1/20 0.33
GRM4 Q14833 1/20 0.32
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31
STK4 Q13043 1/20 0.30
STK3 Q13188 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32669587 0.88 CXCR3 (0.38) COMTFTOMAPK1CXCR3NPC1
SCHEMBL32669636 0.82 COMT (0.37) COMTFTOMAPTKMT2A
SCHEMBL32670093 0.82 FTO (0.56) COMTFTOMAPK1MAPTRAB9A
SCHEMBL32669677 0.80 COMT (0.32) COMTFTO
SCHEMBL32669807 0.79 FTO (0.46) COMTFTOMAPK1MAPTKMT2A
SCHEMBL32669876 0.78 ACHE (0.41) COMTFTONPC1RAB9AKMT2A
SCHEMBL32669976 0.78 FTO (0.40) COMTFTO
SCHEMBL32669608 0.77 FTO (0.37) COMTFTO
SCHEMBL32669684 0.77 FTO (0.47) COMTFTOMAPTKMT2A
SCHEMBL32669799 0.74 FTO (0.43) COMTFTOMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 COMT 52/4885FTO 1/4885MAPK1 1690/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.