Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1052812 | 0.86 | NPC1 (0.74) | NPC1LMNASMYD3HDAC6HTT | |
| SCHEMBL10268218 | 0.84 | NPC1 (0.71) | NPC1LMNASMYD3HDAC6F2 | |
| SCHEMBL112036 | 0.83 | NPC1 (0.69) | NPC1LMNASMYD3HDAC6F2 | |
| SCHEMBL3984997 | 0.82 | NPC1 (0.79) | NPC1LMNASMYD3HDAC6HTT | |
| SCHEMBL1052303 | 0.82 | NPC1 (0.68) | NPC1LMNASMYD3HDAC6HTT | |
| SCHEMBL32670580 | 0.81 | HTT (0.58) | NPC1LMNASMYD3HDAC6HTT | |
| SCHEMBL30265317 | 0.81 | NPC1 (0.81) | NPC1LMNASMYD3HDAC6HTT | |
| SCHEMBL32670673 | 0.80 | LMNA (0.69) | NPC1LMNASMYD3HDAC6HTT | |
| SCHEMBL19710135 | 0.79 | NPC1 (0.78) | NPC1LMNASMYD3HDAC6HTT | |
| SCHEMBL21489973 | 0.79 | NPC1 (0.78) | NPC1LMNASMYD3HDAC6HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260034107-A1 | SUBSTITUTED FUSED IMIDAZOLE DERIVATIVES AND METHODS OF TREATING SICKLE CELL DISEASE AND RELATED COMPLICATIONS | VTV THERAPEUTICS LLC (US) | 2026-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260034107-A1 | SUBSTITUTED FUSED IMIDAZOLE DERIVATIVES AND METHODS OF TREATING SICKLE CELL DISEASE AND RELATED COMPLICATIONS | HBB, HBZ, HBG1 | NPC1 868/4885LMNA 973/4885SMYD3 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.