SCHEMBL3267274

SCHEMBL3267274

CCc1ccc2ccc(Cl)cc2c1C=O

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 1/20 0.42
ALOX15 P16050 1/20 0.39
AHR P35869 1/20 0.36
KCNH2 Q12809 1/20 0.36
TDP1 Q9NUW8 2/20 0.36
CHEK1 O14757 1/20 0.36
GAA P10253 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TYMS P04818 1/20 0.35
ERN1 O75460 1/20 0.34
LMNA P02545 1/20 0.34
PTPN1 P18031 1/20 0.34
FLT1 P17948 1/20 0.33
FLT4 P35916 1/20 0.33
KDR P35968 1/20 0.33
VDR P11473 1/20 0.33
FABP3 P05413 1/20 0.33
FABP4 P15090 1/20 0.33
FABP5 Q01469 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3272561 0.79 MEN1 (0.39) TDP1GAAL3MBTL1TYMSLMNA
SCHEMBL3273914 0.79 LMNA (0.43) PTGER4ALOX15TDP1CHEK1TYMS
SCHEMBL27545246 0.78 TDP1 (0.45) PTGER4TDP1CHEK1TYMSERN1
SCHEMBL3268984 0.77 ERN1 (0.56) TDP1GAAL3MBTL1ERN1
SCHEMBL18015817 0.77 CYP2A6 (0.43) KCNH2CHEK1FABP3FABP4FABP5
SCHEMBL3273985 0.76 ESR1 (0.40) TDP1GAAL3MBTL1ERN1
SCHEMBL3269257 0.75 TDP1 (0.38) PTGER4AHRTDP1CHEK1TYMS
SCHEMBL17429171 0.72 ERN1 (0.53) PTGER4KCNH2TDP1ERN1LMNA
SCHEMBL11216337 0.70 ESR1 (0.55) ALOX15KCNH2LMNAFLT1FLT4
SCHEMBL8601328 0.70 ERN1 (0.49) AHRTDP1GAAL3MBTL1ERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1914229-B1 NOVEL CERCOSPORAMIDE DERIVATIVE DAIICHI SANKYO CO LTD (JP) 2010-06-16 EP disclosed
US-20090036492-A1 Novel Cercosporamide Derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-02-05 US disclosed
CN-101300244-A Novel cercosporamide derivative DAIICHI SANKYO CO LTD (JP) 2008-11-05 CN disclosed
EP-1914229-A1 NOVEL CERCOSPORAMIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2008-04-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090036492-A1 Novel Cercosporamide Derivative GPR119, CBR3, SLC5A2 PTGER4 2540/4885ALOX15 3241/4885AHR 4263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.