Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3271567 | 0.82 | KDM4E (0.32) | KDM4EALDH1A1CYP1A2HPGDCYP2C19 | |
| Hydrochloric Acid SCHEMBL3266036 | 0.81 | KDM4E (0.31) | KDM4EALDH1A1CYP1A2HPGDCYP2C19 | |
| Hydrochloric Acid SCHEMBL6156307 | 0.80 | ALDH1A1 (0.33) | RAB9AL3MBTL1KDM4EALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL3266632 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL6909328 | 0.75 | NPC1 (0.31) | NPC1RAB9AL3MBTL1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5179340 | 0.72 | ALDH1A1 (0.38) | RAB9AL3MBTL1KDM4EALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL6911511 | 0.69 | ALDH1A1 (0.33) | RAB9AL3MBTL1KDM4EALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL5599805 | 0.67 | HPGD (0.34) | RAB9AL3MBTL1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL12023151 | 0.60 | PTPN22 (0.52) | RAB9AL3MBTL1ALDH1A1CYP1A2HPGD | |
| SCHEMBL535635 | 0.59 | HSD17B10 (0.69) | RAB9AL3MBTL1ALDH1A1CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170313-B1 | CROSS-COPOLYMERIZED OLEFIN/STYRENE/DIENE COPOLYMER, PROCESS FOR THE PRODUCTION OF THE SAME AND USES THEREOF | DENKI KAGAKU KOGYO KK (JP) | 2010-06-02 | — | — | EP | disclosed |
| US-6790917-B2 | POLYMERIZING A VINYL COMPOUND IN PRESENCE OF A CATALYST OBTAINED BY COMBINING ORGANOTRANSITION METAL COMPOUND, AN ALUMINUM COMPUND OR ALUMOXANE AND A BORON COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-09-14 | — | — | US | disclosed |
| US-6559234-B1 | Firstly provides a novel olefin/styrene/ diene type cross-copolymer having excellent physical properties and mechanical properties, and a novel, efficient and economically excellent process for its production. It provides an efficient | DENKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2003-05-06 | — | — | US | disclosed |
| US-20020198340-A1 | Process for producing vinyl compound polymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-12-26 | — | — | US | disclosed |
| EP-1170313-A1 | CROSS-COPOLYMERIZED OLEFIN/STYRENE/DIENE COPOLYMER, PROCESS FOR THE PRODUCTION OF THE SAME AND USES THEREOF | DENKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2002-01-09 | — | — | EP | disclosed |