Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6909328 | 0.79 | NPC1 (0.31) | ALDH1A1HPGDKDM4EL3MBTL1RAB9A | |
| Hydrochloric Acid SCHEMBL5179340 | 0.76 | ALDH1A1 (0.38) | ALDH1A1HPGDCYP1A2KDM4ECYP2C19 | |
| Hydrochloric Acid SCHEMBL6156307 | 0.76 | ALDH1A1 (0.33) | ALDH1A1HPGDCYP1A2KDM4ECYP2C19 | |
| Hydrochloric Acid SCHEMBL3267591 | 0.69 | NPC1 (0.32) | ALDH1A1HPGDCYP1A2KDM4ECYP2C19 | |
| Hydrochloric Acid SCHEMBL5599805 | 0.68 | HPGD (0.34) | ALDH1A1HPGDCYP1A2KDM4ECYP2C19 | |
| SCHEMBL535472 | 0.63 | HSD17B10 (0.72) | ALDH1A1HPGDCYP1A2HSD17B10TSHR | |
| SCHEMBL29487823 | 0.63 | HSD17B10 (0.72) | ALDH1A1HPGDCYP1A2HSD17B10TSHR | |
| SCHEMBL29388002 | 0.63 | HSD17B10 (0.69) | ALDH1A1HPGDCYP1A2HSD17B10TSHR | |
| SCHEMBL535635 | 0.63 | HSD17B10 (0.69) | ALDH1A1HPGDCYP1A2HSD17B10TSHR | |
| SCHEMBL30374792 | 0.63 | HSD17B10 (0.69) | ALDH1A1HPGDCYP1A2HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6790917-B2 | POLYMERIZING A VINYL COMPOUND IN PRESENCE OF A CATALYST OBTAINED BY COMBINING ORGANOTRANSITION METAL COMPOUND, AN ALUMINUM COMPUND OR ALUMOXANE AND A BORON COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-09-14 | — | — | US | disclosed |
| US-20020198340-A1 | Process for producing vinyl compound polymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-12-26 | — | — | US | disclosed |