Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6911511 | 0.79 | ALDH1A1 (0.33) | RAB9AL3MBTL1KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3267591 | 0.75 | NPC1 (0.32) | NPC1RAB9AL3MBTL1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5179340 | 0.71 | ALDH1A1 (0.38) | RAB9AL3MBTL1KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6909326 | 0.68 | WDR5 (0.31) | — | |
| Hydrochloric Acid SCHEMBL6156307 | 0.68 | ALDH1A1 (0.33) | RAB9AL3MBTL1KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL5599805 | 0.66 | HPGD (0.34) | RAB9AL3MBTL1KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3271567 | 0.65 | KDM4E (0.32) | KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3266036 | 0.64 | KDM4E (0.31) | KDM4EALDH1A1HPGD | |
| SCHEMBL12023151 | 0.59 | PTPN22 (0.52) | RAB9AL3MBTL1ALDH1A1MAPTHPGD | |
| SCHEMBL535635 | 0.59 | HSD17B10 (0.69) | RAB9AL3MBTL1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6790917-B2 | POLYMERIZING A VINYL COMPOUND IN PRESENCE OF A CATALYST OBTAINED BY COMBINING ORGANOTRANSITION METAL COMPOUND, AN ALUMINUM COMPUND OR ALUMOXANE AND A BORON COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-09-14 | — | — | US | disclosed |
| US-20020198340-A1 | Process for producing vinyl compound polymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-12-26 | — | — | US | disclosed |