Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 7/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3273825 | 0.87 | GHSR (0.47) | GHSRCTSBCTSSCTSK | |
| SCHEMBL3270951 | 0.83 | GHSR (0.42) | GHSRCTSBCTSSCTSKTACR1 | |
| SCHEMBL1401222 | 0.80 | TACR1 (0.44) | TACR1 | |
| SCHEMBL3266957 | 0.80 | GHSR (0.49) | GHSRCTSBCTSSCTSK | |
| SCHEMBL7368069 | 0.79 | GHSR (0.49) | GHSRCTSBCTSSCTSK | |
| SCHEMBL4428281 | 0.79 | GHSR (0.49) | GHSRCTSBCTSSCTSK | |
| SCHEMBL6317705 | 0.77 | GHSR (0.48) | GHSRCTSBCTSSCTSK | |
| SCHEMBL3268342 | 0.77 | GHSR (0.45) | GHSRCTSBCTSSCTSKTACR1 | |
| SCHEMBL3273983 | 0.77 | GHSR (0.45) | GHSRCTSBCTSSCTSKTACR1 | |
| SCHEMBL13307621 | 0.76 | GHSR (0.44) | GHSRCTSBCTSSCTSKTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506969-B1 | Compounds with growth hormone releasing properties | HELSINN THERAPEUTICS US INC (US) | 2010-06-09 | — | — | EP | disclosed |
| EP-1506969-A1 | Compounds with growth hormone releasing properties | NOVO NORDISK A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| EP-1047709-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2004-11-03 | — | — | EP | disclosed |
| WO-1999036431-A9 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2000-07-27 | — | — | WO | disclosed |
| US-6083908-A | TREATING MEDICAL DISORDERS RESULTING FROM DEFICIENCY IN GROWTH HORMONE | NOVO NORDISK A/S (DK) | 2000-07-04 | — | — | US | disclosed |